Tag Archives: tobacco

Biomed Approach to Alzheimer’s Disease?

psychedelic

Alzheimer’s is one of those ‘mysteries’ like autism- but we now know that many kids can recover from autism with what is called a biomedical or ‘biomed’ approach that addresses underlying biological dysfuntions that result in physical or behavioral symptoms. Could adults also recover from Alzheimer’s, or at least halt its progression, with a biomed approach? Some of you may be familiar with NAC (N-acetyl cysteine) and its use in ASD- but look at these results on Alzheimer’s mice!
” The results showed that the mice pretreated with NAC had significantly greater retention in the step through test and shorter latencies in the water maze performance.”
Biochemical markers were also reversed or reduced with NAC pre-treatment.

There was another study that looked at a combo of NAC and acetyl-L-carnitine and S-adenosyl methionine on AD mice, too, with good results.
Behavioral abnormalities correlated with a decline in acetylcholine, which was also prevented by this nutriceutical combination, suggesting that neurotransmitter imbalance may contribute to their manifestation.

What brought me down this trail was looking at factors in RLS (which I have) and often it has to do with low iron or low oxygen transport and this is why iron supplements often help. Didn’t help for me, and neither did any of the other usual things like B vitamins, calcium, magnesium, etc. Usually, smoking makes RLS worse but in some cases, it oddly helps (including for me), and it turns out this is true for a subset of RLS patients and also Parkinsons’ patients, and the connection has to do with acetylcholine, a neurotransmitter.

On a side note, PD drugs like Requip are also used for RLS. These drugs are not that much more effective than placebos and carry the risk of serious side-effects, but perhaps they do work for a subset of RLS patients whose symptoms have to do with an underlying mechanism of action involving the same neurotransmitters that are involved in Parkinson’s Disease. They target dopamine receptors, which are also known to be defective in some patients with Alzheimer’s Disease, who have PD-type symptoms along with their AD.

RLS itself is also sometimes an early warning sign of AD (hope to God that’s not my situation). So there is this connection with both Alzheimer’s and Parkinson’s and RLS, and a connection with improvement in PD and RLS symptoms with nicotine.There has also been some research showing that nicotine patches slightly improve memory in pre-demetia patients.

So we have scientific evidence that nicotine helps alleviate symptoms in some sufferers of AD, PD, and RLS. We also have evidence that these symptoms are related to acetylcholine levels, and that NAC normalizes acetylcholine levels in AD mice. What is the connection with nicotine and acetylcholine?
Nicotine imitates the action of a natural neurotransmitter called acetylcholine and binds to a particular type of acetylcholine receptor, known as the nicotinic receptor.
thebrain.mcgill.ca

I’m not recommending that anyone with RLS, PD, or AD take up smoking. In fact, I’m not recommending anything. But as you see, there is this connection with acetylcholine, RLS, AD and PD. So can it be prevented or reversed? You may have heard of coconut oil for AD but that is another story. Here are the mouse studies on NAC and other natural substances that raise glutathione and affect neurotransmitters and the doses are high but the results look promising and so do studies on NAC for AD in humans. Maybe one day, Alzheimer’s treatment will be focused on using neutraceuticals like NAC. Or maybe not, since there is no big money to be made in that.

For now, preliminary research in mice looks good and I hope we see more human studies on this soon!

http://www.mccordresearch.com/sites/default/files/research/NAC_and_Learning_and_Memory.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952755/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830120/

http://www.neurology.org/content/57/8/1515.short
http://www.ncbi.nlm.nih.gov/pubmed/17914184

http://www.nature.com/npp/journal/v19/n6/abs/1395227a.html

http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_nicotine.html

Image courtesy of Salvatore Vuono / FreeDigitalPhotos.net

Disclaimer: the content of this article is for information purposes only and is not to be construed as medical advice.

Advertisements

The Smoking Gun for Big Tobacco

I did some research a while back and found that lung cancer deaths at the turn of the 20th century, when virtually all the men smoked, were about 1 in 20 000. I’m sure some skeptics would say that’s probably because people didn’t live long enough to get lung cancer, but that’s not quite true. Child mortality was high, but if you survived to your twenties, your life expectancy was fairly close to what it is today- maybe 10 years less, but long enough for you to have the possibility of getting lung cancer. Yet, it was extremely rare. As a tangent, I have read that at that time about 25% of deaths were caused by tuberculosis, which makes me have to sarcastically ask how we ever brought those figures down without a tuberculosis vaccine. Oh yes, there was a vaccine- but it was discontinued because it was found to be useless. They still use it anyway, but not in North America. And oddly, the places that have the highest rates of TB have the highest rates of TB vaccination. But like I said, this is a tangent.

I suppose the skeptics would also doubt that the amazonians who smoke so much get old enough to die of lung cancer either, but even if their life expectancy is shorter, some of those who live to a ripe old age should at least get lung cancer, but they don’t. Same turned out to be true for the indigenous people of Papua, New Guinea.

What I found was that lung cancer did not rise in tandem with smoking rates, but with the introduction of phosphate fertilizers, made from apatite rock and containing the radioactive element Polonium. Since Polonium bio-accumulates, tobacco crops over the years have produced yields containing more and more of this carcinogenic crap. This is known to be a fact, and yet you will never hear about it. So it makes me kind of sick, so to speak, when the government comes out with their anti-smoking laws and mandatory nauseating pictures on cigarette packs and does nothing to outlaw radioactive, carcinogenic phosphate fertilizer. Given our corporation-run system, this is not all that surprising as growing the plants without this product results in about 30% decrease in crop yields. Once again, profits win out over public interest.

And then, after spending so much money on enforcing smoking laws and funding anti-smoking health warning campaigns, the government decides to put carpet glue in the cigarette papers- to protect you from house fires! I’m pretty sure far more people die from cigarette-induced cancer than from house fires. But then again, as a recent study funded by the tobacco industry discovered, smoking deaths are good for the economy. So let those bastards smoke carpet glue while you’re at it and speed up the economic recovery!

What was especially unfortunate was Barb Tarbox, the poster child for cigarette-induced lung cancer, going around to schools freaking the kids out showing them her bald head and blaming herself for being the ‘world’s biggest idiot’ smoking two packs a day. Yes, she had been warned, cigarettes do cause cancer, and smoking two packs a day is a bit excessive (you have to wonder how someone even finds the time for it), and it’s good to make the kids not want to smoke. But in the end, wouldn’t it have done us all a greater service if Barb had used her public voice to call the tobacco companies and the government out on what they were really doing that was making people sick: not selling tobacco, but selling highly adulterated tobacco?

It seems to me that God makes it pretty clear to us which plants are good for us and which ones are not: those that are not immediately make us sick upon ingestion. This is logical in order for a caveman to survive. God wouldn’t put things around that would be ok to ingest for a while and then strike you with a horrible disease to make you die a slow death- that would be a bit of a mean trick.

So, as someone who believes in God and the perfection of his creation, I find it annoying that everyone is on the bandwagon to demonize the tobacco plant. What we need are regulatory bodies that are not run by people who serve corporations- or the Devil, for that matter, with the two usually going hand-in-hand anyway. Big Tobacco, not the tobacco plant, is the killer.

Below is a fascinating discussion with David Wolfe on smoking various herbs, including tobacco.
I was thinking of it today because I found a local shop that sells all these unusual herbs like mullein, mugwort, yerba santa, and sage. I am going to try smoking some of them and I’ll let you know what happens. If I post a video about it, it means I didn’t die and it’s probably safe enough for you to try it.